Providing rapid evidence-based responses to questions about medications prescribed in Canada
CNODES is a national network of provincial/regional centres that provide rapid evidence-based responses to questions about the safety and effectiveness of medications prescribed in Canada. These studies enable CNODES to respond rapidly to questions raised by Health Canada, the Canadian Agency for Drugs and Technologies in Health, and provincial Ministries of Health when evaluating and monitoring prescription drug usage, safety, and effectiveness.
CNODES uses population databases from eight Canadian provinces and two international databases (UK Clinical Practice Research Datalink (CPRD) and US MarketScan), which include more than 100 million patients.
The Health Quality Council is the Saskatchewan site of the national CNODES network. There are also offices in British Columbia, Alberta, Manitoba, Ontario, Quebec, Nova Scotia, and Newfoundland and Labrador. Each lab conducts research independently, but study results inform a collective response to overarching research queries.
The Health Quality Council’s CNODES team has been involved on projects regarding:
- The use of systemic oral fluoroquinolones in Canada
- Direct oral anticoagulants for the treatment of venous thromboembolic events
- The utilization and comparative effectiveness of rheumatoid arthritis medications
- The utilization and adverse outcomes of ondansetron and fluconazole therapy during pregnancy
- The utilization, effectiveness, and safety of SGLT2 inhibitors among patients with type 2 diabetes mellitus
- Local researchers contribute to nation-wide study on overprescribed, common antibiotic
- What is CNODES and what does it do?
- Some Saskatchewan women become pregnant while on acne medication known to cause birth defects, despite Canadian prevention guidelines
- HQC contributes to new study on anti-diabetic incretin-based drugs, published in New England Journal of Medicine
- HQC part of study that finds risk in potent cholesterol-lowering drugs
- First study published by CNODES recognized by top nephrology journal
- HQC part of new study on proton pump inhibitors
- Statin study co-authored by HQC published in prestigious British Medical Journal
Contact the CNODES Saskatchewan team
To contact the CNODES Saskatchewan team, please visit our Contact Us page for the most up-to-date contact information.Contact Us